此課程為本所博士班必修課，係介紹整合性生命科學的重要趨勢，強調以分子為基礎去闡釋生命現象，給合分子生物、細胞生物、結構生物及化學生物領域。課程內容從基礎知識到研究技術、當前觀念及未來發展。期許學生能藉此跨越個人背景之限制而拓展視野，同時能體會各種目前最先進之研究模式及研究技術，以期未來運用到個人的研究上或加強與他人的合作。課程分四段落；包括細胞分子生物、模式生物與功能性基因體、化學全物與藥物發現及結構生物與蛋白質體。每週課程主題如下；
Epigenetic and gene regulation，Signal transduction and cancer development，Cell migration and cytoskeleton，Stem cells，Zebrafish as a model organism: from disease model to drug screening，Drosophila as a model organism for biomedical research，Adventures in modern bacteriology: Cell division in 3 dimensions，Common Mechanisms in Biological Chemistry，Summary of Biological Transformations，Enzyme Catalysis，Visualizing and Measuring protein-ligand interactions, thermodynamics, kinetics, and spectroscopy，From Genomics to Proteins and Peptide Chemistry; Omics Integration and Systems Biology，MS approach to understand Proteome Dynamics and Modification，Protein Complexes, Assembly and Structural Genomics，Glycosylation and Glycomics